Can Cannabidiol Help Prevent and Treat Gastrointestinal Disorders? Insights from Experts

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Numerous people search for a “cannabis store near me” to buy marijuana, whether to alleviate their condition or for recreational enjoyment. It is widely recognized that cannabis products may help relieve symptoms such as anxiety, depression, pain, nausea, and vomiting. Have you considered their effects on gastrointestinal disorders?

Key Takeaways:

• Cannabinoids in the cannabis interact through the endocannabinoid system in the GI tract.
• cannabis and pain medications can assist in managing Irritable Bowel Syndrome symptoms.
• cannabis Sativa serves various purposes, but it is primarily known for its recreational and medical uses.

Gastrointestinal Disorders and Just Cannabis Canada

The dietary effects of nutraceuticals on gastrointestinal (GI) health are widely acknowledged. Certain diets may prevent or reduce various GI issues. Researchers have identified and evaluated the food components responsible for these benefits.

Among the plant-derived nutraceuticals that may help treat GI disorders are those from cannabis. cannabis refers to preparations from the cannabis Sativa plant, an aromatic annual flowering herb.

John M. McPartland noted in a scientific review that the Cannabaceae family includes the genera Cannabis, Humulus, and Celtis. Within the cannabis genus, sativa consists of three varieties: Sativa, Indica, and Ruderalis. Depending on the variety, cannabis serves multiple purposes, such as fiber production, oil extraction, and primarily, recreational or medicinal applications.

The Impact of the cannabis

Receptors and ligands of the endocannabinoid system are found throughout various areas and systems, both within and outside the GI tract, which are essential for regulating GI functions. Due to cannabinoid receptors’ presence, cannabinoids, including non-psychoactive phytocannabinoids, assist in modulating GI functions in health and disease. The ECS plays a role in regulating motility, secretion, epithelial barrier function, and viscerosensitivity.

Irritable Bowel Syndrome (IBS)

IBS has various contributing factors, affecting 10–20% of people in developed nations. It presents as functional gastrointestinal disturbances without identifiable organic origins.

The enhancement of the antinociceptive properties of cannabinoids amidst inflammation highlights the ECS’s significance in visceral hypersensitivity. This finding sheds light on the mechanisms behind IBS and other gastrointestinal disorders, suggesting promising therapeutic avenues for abdominal and visceral pain relief.

Cannabinoids alone may not provide significant relief in reducing visceral hypersensitivity in IBS patients. Considering combinations with other pain-modulating agents, like opioids, is an intriguing alternative worth exploring.

Inflammatory Bowel Disease (IBD)

IBD, including Crohn’s disease (CD) and ulcerative colitis (UC), poses a complex challenge to the GI tract, arising from environmental, genetic, and epigenetic factors.

Cannabidiol exhibits strong anti-inflammatory effects across various models of intestinal inflammation in mice and rats, as highlighted in a study published in the Journal of Frontiers in Pharmacology. Both local and systemic administration of CBD resulted in a dose-dependent improvement in disease indicators:

• Reduction of structural damage
• Mitigation of inflammation-related increases in various cytokines, chemokines, and oxidative stress markers.

A study from the Inflammatory Diseases Journal revealed that 90% of patients reported treatment-related adverse effects from the botanical extract compared to 48% receiving the placebo.

A trend emerged indicating enhanced quality of life scores and a positive shift in patients’ overall impressions, suggesting that the CBD-rich botanical extract may offer therapeutic advantages to those who can tolerate its effects.

Gastrointestinal Cancer

GI cancers, including colorectal cancer (CRC), rank among the most frequently diagnosed conditions in the general population.

Numerous studies have demonstrated CBD’s antiproliferative effects in colorectal cancer models. CBD can protect DNA from oxidative stress, boost endocannabinoid levels, and inhibit the proliferation of colorectal cancer cells in vitro.

The confirmation of CBD’s chemopreventive properties came from investigations focusing on AOM-induced colon cancer. A dosage of 1 mg/kg led to a significant reduction: ACF decreased by 67%, while the number of tumors and polyps dropped by 66% and 57%, respectively. Increasing the concentration to 5 mg/kg showed efficacy primarily in preventing polyp formation.

THC induces apoptosis in colorectal cancer cells by activating the CB1 receptor.

Nausea and Vomiting

Positive effects of CBD arise when combined with THC, as shown in a study published in the British Journal of Clinical Pharmacology. CBD’s anti-nausea and anti-emetic properties may stem from the indirect stimulation of somatodendritic 5-HT1A receptors in the dorsal raphe nucleus, leading to decreased 5-HT release in specific forebrain regions.

Gastroesophageal Reflux Disease (GERD)

Cannabinoids impede transient LES relaxations via a CB1-dependent mechanism in both dogs and ferrets, according to a study from the Journal of cannabis and Cannabinoid Research. These findings are significant, as transient LES relaxations are the primary mechanism behind gastroesophageal reflux disease.

cannabis for GI Issues

Conclusion

Multiple studies indicate that cannabinoids’ benefits extend beyond the well-known psychoactive compound THC to include non-psychoactive molecules like CBD, which have received comparatively less attention. The cannabis plant influences the GI system by interacting with the ECS to trigger multiple functions that can aid in managing symptoms of specific GI conditions.

Frequently Asked Questions

What can you expect when buying from online cannabis stores?

1. Accessing your cannabis products in Canada from Just Cannabis Canada opens up various options featuring both classic favorites and new items.
2. You can expect additional benefits like special offers, reliable payment methods, and shipping options covering most provinces.
3. Essential resources, such as a blog section or contact page, are available to provide insights or assistance during your shopping experience.
4. As part of the purchase process, you’ll need to verify your age by presenting identification.
5. Some stores include taxes in the total price of their products, while others calculate it at checkout.
6. Some dispensaries accept online payments like Interac E-Transfer, while others allow cash on delivery.

What is the measurement unit when buying from a cannabis website?

There are two primary measurement forms: metric and imperial units. On a Just Cannabis Canada, you’ll find measurements in grams or ounces, allowing you to locate products like 3.5 grams or 1/8 ounces.

What distinguishes cannabis for medical use from that used recreationally?

Medical cannabis and recreational cannabis come from the same plant species, yet their different effects and intended uses set them apart. Medical cannabis serves as a therapeutic aid for specific health conditions, often having a higher CBD composition than its recreational counterpart.

Are there ready-made joints available in a cannabis store?

Yes. These are available as pre-rolls. cannabis pre-rolls, or pre-rolled joints and blunts, are convenient options for those who prefer ready-to-use cannabis. The popularity of pre-rolled joints infused with cannabis concentrates is on the rise.

Do cannabis online stores have a physical shop?

Not all online stores have physical locations, allowing you to have your purchases delivered directly to your doorstep instead of needing to pick them up after placing an order.

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